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. 2015 Apr 14;7(7):918–929. doi: 10.15252/emmm.201404803

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© 2015 The Authors. Published under the terms of the CC BY 4.0 license

This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Analysis of PARP-1 inhibition on DSB repair

XRCC4^wt and XRCC4^m/m cells irradiated with 0.5 Gy of γ-rays were exposed to the PARP1 inhibitor 3′-AB or to solvent (DMSO). The γ-H2AX foci number is the mean ± SD of three independent experiments. *P < 0.05 (XRCC4^m/m + 3′-AB versus XRCC4^m/m + DMSO), ***P < 0.001 (XRCC4^m/m + 3′-AB versus XRCC4^wt + 3′-AB), two-way ANOVA, Bonferroni post hoc test.