Table 3. Effect of HCV co-infection on time from HIV seroconversion to CD4<350 cells/mm3, AIDS or death by HCV infection status and HCV infection duration: UK Register of HIV seroconverters.
| Follow-up time (years) | HCV infection status/duration (years) | |||
|---|---|---|---|---|
| HCV uninfected | <1 | 1–2 | >2 years | |
| <2: Number of individuals (Number of events) | 1448 (471) | 34 (16) | 18 (6) | 19 (0) |
| Unadjusted hazard ratio [95% CI] | 1 | 2.91 [1.77, 4.79] | 0.80 [0.36, 1.79] | ** |
| Adjusted* hazard ratio [95% CI] | 1 | 2.58 [1.51, 4.41] | 0.59 [0.23, 1.51] | ** |
| 2–4: Number of individuals (Number of events) | 507 (196) | 4 (3) | 13 (11) | 20 (6) |
| Unadjusted hazard ratio [95% CI] | 1 | 3.53, [1.13, 11.06] | 3.48 [1.89, 6.40] | 0.69 [0.31, 1.56] |
| Adjusted* hazard ratio [95% CI] | 1 | 3.80 [1.20, 12.03] | 3.56 [1.91, 6.62] | 1.00 [0.31, 3.24] |
| >4: Number of individuals (Number of events) | 285 (208) | 11 (6) | 3 (2) | 20 (18) |
| Unadjusted hazard ratio [95% CI] | 1 | 2.06 [0.90, 4.70] | 1.18 [0.29, 4.76] | 0.62 [0.37, 1.01] |
| Adjusted* hazard ratio [95% CI] | 1 | 2.03 [0.88, 4.71] | 1.43 [0.34, 5.90] | 0.95 [0.45, 1.99] |
*Adjusted for sex, age at cART (per 10 years), diagnosis during acute HIV infection, decade of HIV seroconversion and risk group.
**Not possible to estimate the hazard ratio because the estimation algorithm did not result in convergence towards an estimate.