Skip to main content
. 2015 Jul 30;10(7):e0133713. doi: 10.1371/journal.pone.0133713

Fig 7. Intramuscular injection of p29 rescues muscle atrophy and weakness in caveolin 3-deficient LGMD1C model mice.

Fig 7

(A) Effect of p29 on in vitro myostatin activity in the HEK293-(CAGA)12-luciferase system. Cells were stimulated with 10-ng/ml myostatin and simultaneously exposed to increasing concentrations (2, 20, 200, or 2000 nM) of p29 or albumin (control). All experiments were performed triplicate, repeatedly twice. (B) Appearance of TA muscles at 28 days after local injection of p29 (20 nmol) or albumin (C, control) into the ipsilateral and contralateral TA muscles of wild-type and CAV3P104L Tg mice. (C) Weights of TA muscles injected with 20 nmol p29 or albumin in wild-type and CAV3P104L Tg mice (n = 10). *P < 0.05. (D) Weights of caveolin 3-deficient TA muscles injected with different amounts of p29 or albumin (right, n = 10). *P < 0.05. (E) Specific force of the TA muscle in wild-type (left) and CAV3P104L Tg (right) mice treated with p29 or albumin. *P < 0.05. Values are the means ± SD (n = 10).