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. 2015 Jul 30;10(7):e0133316. doi: 10.1371/journal.pone.0133316

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© 2015 Curie et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — There was a significant effect of age on placebo effect size (g), represented by higher placebo responses in the youngest patients included in this meta-analysis (p < .05). It is possible that the results are explained by stronger placebo-by-proxy effects in young children, as parents and caregivers express high encouragement, attention and support to babies. The intensive care and attention given to young children may wane over time and thus lessen the placebo effects in older ID patients.