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. Author manuscript; available in PMC: 2016 Jul 21.
Published in final edited form as: Cell Rep. 2015 Jul 9;12(3):449–461. doi: 10.1016/j.celrep.2015.06.023

Figure 6. UBE3A deficiency-induced changes in LTP properties.

Figure 6

(A) Two TBS (arrows) separated by 60 min could induce further potentiation in hippocampal slices from WT mice, while neither the first or second TBS induced LTP in hippocampal slices from AS mice.

(B) A second TBS(2) applied 10 min after the first TBS(1) did not induce further potentiation in slices from WT mice. However, the same TBS2 was able to induce LTP in hippocampal slices from AS mice.

(C) With apamin pre-application, TBS2 applied 10 min post TBS1 was not able to further enhance LTP in AS mice.

(D) TBS elicited a decrease in the number of SK2-positive synapses in both WT and AS mice. Shown are representative images of SK2 (red) and PSD95 (green) immunostaining in CA1 region of WT and AS mice (Scale bar = 10 μm).

(E) Quantitative results of synapses dually labelled by anti-SK2 and -PSD95 antibodies in different experimental groups (* p < 0.05, n = 3 slices from 3 mice/group, one-way ANOVA followed by Bonferroni test). See also Figure S7.

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