Table 1.

Significant (P<5×10⁻⁸) association results for pancreatic cancer

			Stage 1				Stage 2
Chra SNP Positionb Gene	Effect Allele (Minor)/Reference Allele	Statistic	PanC4 4,164 cases 3,792 controls	PanScan 1 1,856 cases, 1,890 controls	PanScan 2 1,618 cases and 1,682 controls	Combined Stage 1c 7,638 cases 7,364 controls	PANDoRA 2,497 cases 4,611 controls	Combined Stage 1&2d 9,925 cases 11,569 controls
17q25.1h rs11655237 70,400,166 LINC00673	T/C	mafe cases;controls	0.146; 0.110	0.139; 0.129	0.149; 0.116		0.135; 0.114
		infof	0.963	g	g
		OR (CI)g	1.38 (1.26 – 1.52)	1.09 (0.96 – 1.25)	1.34 (1.16 – 1.55)	1.27 (1.19 – 1.36)	1.24 (1.10 – 1.40)	1.26 (1.19 – 1.34)
		p-value	1.38×10−10	1.95×10−1	2.95×10−4	6.74×10−12	6.40×10−4	1.42×10−14
17q25.1h rs7214041 70,401,476 LINC00673	T/C	maf cases;controls	0.148; 0.112	0.140; 0.133	0.150; 0.117		0.139; 0.117
		info	g	0.966	0.96
		OR (CI)	1.38 (1.26 – 1.51)	1.07 (0.93 – 1.22)	1.33 (1.15 – 1.53)	1.26 (1.18 – 1.35)	1.25 (1.11 – 1.41)	1.26 (1.19 – 1.34)
		p-value	1.95×10−10	3.36×10−1	3.69×10−4	2.67×10−11	3.37×10−4	2.88×10−14
2p13.3 rs1486134 67,639,769 ETAA1 (2236bp 3′)	G/T	maf cases;controls	0.302; 0.275	0.305; 0.292	0.305; 0.276		0.292; 0.273
		info	g	g	g
		OR (CI)	1.14 (1.06 – 1.22)	1.06 (0.96 – 1.18)	1.15 (1.03 – 1.28)	1.13 (1.08 – 1.19)	1.16 (1.06 – 1.27)	1.14 (1.09 – 1.19)
		p-value	5.96×10−5	1.57×10−1	5.18×10−3	8.35×10−7	9.42×10−4	3.36×10−9
7p13 rs17688601 40,866,663 SUGCT	A/C	maf cases;controls	0.241; 0.263	0.218; 0.254	0.237; 0.268		0.254; 0.277
		info	g	g	g
		OR (CI)	0.89 (0.83 – 0.96)	0.82 (0.73 – 0.91)	0.85 (0.76 – 0.94)	0.87 (0.82 – 0.91)	0.91 (0.83 – 1.00)	0.88 (0.84 – 0.92)
		p-value	1.98×10−3	1.66×10−4	8.72×10−3	9.77×10−8	3.93×10−2	1.41×10−8
3q29 rs9854771 189,508,471 TP63	A/G	maf cases;controls	0.328; 0.362	0.336; 0.366	0.325; 0.356		0.341; 0.356
		info	g	0.998	0.998
		OR (CI)	0.86 (0.81 – 0.92)	0.88 (0.80 – 0.90)	0.87 (0.79 – 0.97)	0.87 (0.83 – 0.92)	0.93 (0.86 – 1.01)	0.89 (0.85 – 0.93)
		p-value	3.10×10−5	7.94×10−3	1.55×10−2	4.08×10−8	1.01×10−1	2.35×10−8

^aCytogenetic regions according to NCBI Human Genome Build 37 and NCBI’s Map Viewer

^bSNP position according to NCBI Human Genome Build 37

^cResults from the Combined Stage 1 meta-analysis of PanC4, PanScan 1, and PanScan 2

^dResults from the Combined Stage 1 and 2 meta-analysis of PanC4, PanScan 1, PanScan 2, and PANDoRA

^eMAF- minor allele frequency

^fQuality of imputation metric. See online methods for more detail. If snp is genotyped and not imputed, a ‘g’ is reported

^gAllelic Odds Ratio and corresponding 95% Confidence Interval

^hR²>0.95