Figure 5.
Unintended structural effects of amino acid selection on the design simulation. The WT-CISK-PX and DS-CISK-PX structures are aligned by Cα-superposition with F80/I77 from WT/DS highlighted. The loss of the aromatic F80 side-chain is filed by the K67 side-chain group for DI-XIAP-PX on the opposing loop.