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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Struct Biol. 2015 Jun 11;191(2):197–206. doi: 10.1016/j.jsb.2015.06.009

Figure 5.

Figure 5

Unintended structural effects of amino acid selection on the design simulation. The WT-CISK-PX and DS-CISK-PX structures are aligned by Cα-superposition with F80/I77 from WT/DS highlighted. The loss of the aromatic F80 side-chain is filed by the K67 side-chain group for DI-XIAP-PX on the opposing loop.