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Low entropy residues in structure profile guide the DS-CISK-PX structure to alternate PX domain conformations. WT-CISK-PX, WT-p40PX(PI), and DS-CISK-PX X-ray structures are in green, orange and blue, respectively. Residue numbers follow a similar coloring scheme. Electron density map from the DS-CISK-PX X-ray structure shown in grey mesh (2Fo-Fc map contoured at 2.0 sigma).
