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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: J Pharmacol Toxicol Methods. 2015 Apr 22;74:1–6. doi: 10.1016/j.vascn.2015.04.004

Figure 3.

Figure 3

Effect of buprenorphine in Group 3. Data in all but panel D are expressed as means ± SEMs. A. Buprenorphine (0.05 mg/kg, 1 dose) did not affect transit times. Three equally spaced doses of buprenorphine had a profound effect on the transit times of some but not all rats. B. Both 1 dose and 3 doses of buprenorphine led to decreased total daily pellets compared to both other trials. C. There was no significant difference in food consumed in the 3 trials. D. Visual fecal pellet counts were highly correlated with counts made using the photographs alone. E. Hourly fecal pellet discharge for the 3 trials showed qualitative differences. Both 1 Dose and 3 Dose trials were significantly different from Baseline, but did not differ from each other (see text for details of ANOVA). F. The mean area under the curves differed by trial, with 1 Dose and 3 Dose trials being significantly different from Baseline but not from each other. * = significantly different from indicated groups.