Table 2. Rheumatoid arthritis (RA) activity/severity measures and their association with risk of cardiovascular disease.

RA activity/severity measure	Variables	Hazard ratio* (95% CI)	P value
Flare/	Daily Flare	0.96 (0.46, 1.99)	0.91
Intermediate/	Daily Intermediate activity	1.30 (0.77, 2.20)	0.33
Remission	Daily Remission	1 (reference)
	Years in Flare	1.01 (0.89, 1.44)	0.40†
	Years in Intermediate Activity	0.92 (0.81, 1.04)
	Years in Remission	1 (reference)
Acute Flare/	Daily Acute Flare	1.70 (0.62, 4.64)	0.30
Intermediate/	Daily Intermediate activity	1.39 (0.80, 2.41)	0.24
Remission	Daily Remission	1 (reference)
	Years in Acute Flare	1.87 (1.04, 3.35)	0.056†
	Years in Intermediate Activity	0.95 (0.84, 1.08)
	Years in Remission	1 (reference)
CIRAS	Daily CIRAS	1.27 (1.11, 1.46)	0.0005
	Daily Cumulative Average CIRAS	1.38 (1.12, 1.70)	0.002
	Years in Low CIRAS tertile	1 (reference)	0.006†
	Years in Medium CIRAS tertile	1.08 (0.98, 1.20)
	Years in High CIRAS tertile	1.18 (1.06, 1.31)
RARBIS with medications	Daily RARBIS with medications	1.10 (1.01, 1.21)	0.04
	Daily Cumulative Average RARBIS	1.16 (1.03, 1.30)	0.01
	Years in Low RARBIS tertile	1 (reference)	0.18†
	Years in Medium RARBIS tertile	0.98 (0.90, 1.07)
	Years in High RARBIS tertile	1.06 (0.99, 1.14)
RARBIS without medications	Daily RARBIS without medications	1.15 (1.04, 1.27)	0.006
	Daily Cumulative Average RARBIS	1.17 (1.04, 1.33)	0.01
	Years in Low RARBIS tertile	1 (reference)	0.052†
	Years in Medium RARBIS tertile	1.11 (1.00, 1.24)
	Years in High RARBIS tertile	1.07 (1.00, 1.14)

^*adjusted for age, sex, year of RA, cardiovascular risk factors (hypertension, diabetes mellitus, dyslipidemia, smoking status) and antirheumatic medications (methotrexate, hydroxychloroquine, other disease modifying anti-rheumatic drugs, biologics, corticosteroids)

RARBIS = Rheumatoid Arthritis medical Records-Based Index of Severity (RARBIS); CIRAS = Claims-based Index of Rheumatoid Arthritis Severity

^†generalized test of a difference between the tertiles