Fig 1.

Schematic representation of CPX-351 (cytarabine:daunorubicin) liposome injection. The liposomes are bilamellar with a diameter of 100 nm for the outer vesicle. The membrane is composed of desaturated phosphatidylcholine (DSPC): distearylphosphatidylglycerol (DSPG):cholesterol in a 7:2:1 molar ratio. The active agents, cytarabine and daunorubicin, are encapsulated in the aqueous space of both vesicles at a 5:1 molar ratio. The liposomes are suspended in phosphate-buffered sucrose, pH 7.4. While inside the liposome, daunorubicin is complexed with copper as copper gluconate, giving CPX-351 its characteristic purple color. The strength of CPX-351 is 5 units/mL, where 1 unit = 1.0 mg cytarabine plus 0.44 mg daunorubicin (base).