Table 4. Univariate and multivariate analyses for recurrence and progression-free survival.
| Variables | Recurrence free survival | Progression free survival | ||||
|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||
| P value | Hazard ratio (95% C.I) | P value | P value | Hazard ratio (95% C.I) | P value | |
| Substage | 0.704 | N/A | N/A | 0 | 1.999 (1.355-2.949) | < 0.001 |
| Tumor size | 0.042 | 1.595 (0.989-2.572) | 0.055 | 0.317 | N/A | N/A |
| Multifocality | 0.22 | N/A | N/A | 0.041 | 1.360 (0.490-3.775) | 0.555 |
| Tumor grade | 0.168 | N/A | N/A | 0 | 2.009 (0.660-6.114) | 0.219 |
| CIS | 0.569 | N/A | N/A | 0.95 | N/A | N/A |
| LVI | 0.616 | N/A | N/A | 0 | 1.861 (0.177-19.611) | 0.605 |
| HER2 IHC | 0 | 3.459 (1.223-9.781) | 0.019 | 0 | 84.642 (11.661-614.393) | < 0.001 |
| HER2 SISH | 0.195 | N/A | N/A | 0 | 0.086 (0.009-0.800) | 0.031 |
Only risk factors with P values<0.05 were included in the multivariate analysis. IHC, immunohistochemistry; SISH, silver in-situ hybridization; CI, confidence interval; N/A, not available.