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Cooperative salt-bridge network to stabilize the core M region. Evolution of backbone r.m.s.d. (top), inter-domain angles (middle), and salt-bridge distances (bottom) as a function of time during equilibrium simulations of wild type α-catenin (trajectory 2) and three mutants (trajectories 5–7). Inter-domain angle is measured as the angle between the principal axes of pairwise domains.
