TABLE 4.
Calcium spark characteristics of RGS4−/− mice and RGS4+/+ alone, with ET-1 and 2-APB then ET-1
Amplitude (F/F0) full-width at half-maximum amplitude (FWHM, μm), duration at half-maximum amplitude (FDHM, ms), time to peak (TtP, ms), and Tau (ms). 2-APB abolished the sparks and thus parameters could not be measured in these conditions.
| Means ± S.E. |
|||||
|---|---|---|---|---|---|
| Amplitude | FWHM | FDHM | TtP | Tau | |
| RGS4+/+ | 0.76 ± 0.02 | 2.26 ± 0.04 | 34.08 ± 0.91 | 22.39 ± 1.82 | 38.59 ± 1.82 |
| RGS4−/− | 0.62 ± 0.02 | 2.44 ± 0.13 | 46.27 ± 1.36 | 29.70 ± 1.26 | 70.11 ± 8.85 |
| RGS4+/+ with ET-1 | 0.61 ± 0.03 | 2.46 ± 0.08 | 36.68 ± 1.92 | 22.77 ± 1.57 | 42.18 ± 3.87 |
| RGS4−/− with ET-1 | 0.50 ± 0.01 | 2.34 ± 0.04 | 33.21 ± 0.89 | 23.63 ± 1.07 | 37.67 ± 2.32 |