FIGURE 4.

Open field testing in the ROSA-stop transgenic mice. The open field parameters for the N463-Q148, N536-Q148, N552-Q148, and N586-Q148 transgenic ROSA HD transgenic mouse models were measured at 4 months of age (A) and 5 months of age (B). Recordings of 22 parameters during the open-field test in the floor and vertical plane were monitored to evaluate spontaneous locomotor activity. The measurements shown are noted in the panels. An n = 5–16 animals were tested at 14 weeks for 30 min during the dark cycle. Statistical significance is noted in the graphs.