Fig. 1.

Uptake of radioiodine in the parotid (a) and submandibular glands (b) on the SPECT-CT scan, performed 7 days after radioiodine therapy. c The NIS is mainly expressed in the striated ducts of salivary glands (S), and to a lesser extent in the intercalated (rectangle) and excretory ducts (E). Acini (A) do not express NIS. Reprinted with permission [6], © 2013 Mary Ann Liebert Inc. d Schematic representation of a salivary gland, with proposed locations of stem cells in excretory and striated ducts, and progenitor cells within the striated and intercalated ducts. The stem cell pool supplies the progenitor cell pool, which in turn replenishes the population of duct and acinar cells. Both stem and progenitor cells have the capacity to self-renew and differentiate. Reprinted with permission [10], © 2013 Wiley.