Table 1.

Regulation of iron regulatory proteins in macrophages^a

stimuli	iron		heme		inflammation		pRBCs		Salmonella	Refs
hepcidin	no effect	[36]	n.a.		↑ transcriptional e.g., IL-6, LPS	[36, 37]	↑ transcriptional	[38, 76]	↑ transcriptional	[47]
ferroportin	↑ post-transcriptional	[78]	↑ transcriptional	[26, 79]	↓posttranslational by hepcidin	[36, 39]	n.a.		↑ transcriptional /no effect	[44, 47]
	↑ transcriptional	[36]			↓ transcriptional LPS, IFNγ, TNFα
H- ferritin	↑ post-transcriptional	[78]	↑ transcriptional	[26]	↑transcriptional?		n.a.		↑ transcriptional /no effect	[44, 47]
HO-1	n.a.		↑ transcriptional	[26, 79]	↑ IL- 10, not LPS	[80]	↑ transcriptional	[63]	↑ transcriptional	[44, 47]
DMT-1	↓posttranslational	[78]	no effect	[81]	↑ transcriptional LPS, IFNγ, TNFα	[39]	n.a.		↑ transcriptional	[44, 47]
	↑ transcriptional?	[36]
Nramp-1	n.a.		↑ transcriptional	[81]	↑ transcriptional LPS	[82]	n.a.		n.a.

^aOverview of how iron regulatory proteins of macrophages (vertical column) are affected by various components related to malaria infection (iron, heme, inflammatory stimuli, pRBCs) as well as by Salmonella. The consequence of these alterations is discussed in Figure 1.

Abbreviations: LPS, lipopolysaccharide; TNFα, tumor necrosis factor α; IFNγ, interferon γ; n.a., no reports available.