Fig. 6.

Differential basal and poly I:C-induced expression of inflammatory transcripts in WT and IFNAR1^−/− mice. (a) Basal expression of multiple inflammatory transcripts in IFNAR1^−/− mice are expressed as a fraction of WT expression levels and comparisons between WT and IFNAR1^−/− were made by Student’s t tests, with statistical significance denoted by ⁺p < 0.0001 and ^#p = 0.0021. (b–f) Expression of the same transcripts 3 h post-challenge with saline or poly I:C (12 mg/kg i.p.): (b) IRF7, (c) CCL2, (d) IDO, (e) COX-2 and (f) IL-10. Data are expressed as mean ± SEM and analysed by two-way ANOVA with treatment and strain as factors, n = 5 for WT and n = 6 for IFNAR1^−/−. Significant interactions between strain and treatment are denoted by ^∗∗∗p < 0.001 and a significant main effect of strain is denoted by ^∗p < 0.05 (d).