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. 2015 Aug;48:274–286. doi: 10.1016/j.bbi.2015.04.009

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 8 — Sickness behaviour post-IL-6 and post-poly I:C ± IL-6 challenges. (a–c) The sickness response of C57BL/6 and IFNAR1^−/− mice to saline or interleukin-6 (50 μg/kg i.p.), as assessed by burrowing (a), rearing activity in the open field (b) and % body weight loss (c). Data are expressed as mean ± SEM, n = 8 for WT + saline, n = 7 for WT + IL-6, n = 10 for IFNAR + saline, n = 10 for IFNAR + IL-6. (d–f) The sickness response of C57BL/6 and IFNAR1^−/− mice to poly I:C + vehicle (12 mg/kg i.p.) versus poly I:C + IL-6 (50 μg/kg i.p.) challenges on burrowing (d), rearing (e) and body weight (f). Data are expressed as mean ± SEM, n = 11 for WT + pI:C and IFNAR + pI:C, n = 12 for IFNAR + pI:C + IL-6 and n = 5 for WT + pI:C + IL-6. Rearing activity at 3 h was analysed by two-way ANOVA (b, e) with strain and treatment as factors. Burrowing at 9 h (a, d) and body weight change (c, f) were analysed by three-way ANOVA with strain, treatment and time as factors. * denotes significant difference between IFNAR + pI:C + vehicle and IFNAR + pI:C + IL-6 at 9 h after a significant two-way ANOVA at that time (p < 0.05). # denotes significant main effect of IL-6 treatment by two-way ANOVA (e).