Table 2.
Univariate and multivariate analysis of factors influencing local recurrence-free survival in 33 patients with M0 tumors
| Variable | No. of cases | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| 2-year LRFS rate | 5-year LRFS rate | p-Value | HR | 95 % CI | p Value | ||
| Sex | 0.348 | ||||||
| Male | 24 | 83.1 | 69.3 | ||||
| Female | 9 | 77.8 | 46.7 | ||||
| Age at presentation (years) | 0.838 | ||||||
| ≤30 | 11 | 72.7 | 72.7 | ||||
| >30 | 22 | 86.4 | 57.6 | ||||
| Location | 0.020 | NS | |||||
| Distal | 18 | 100 | 75.0 | ||||
| Proximal | 15 | 58.7 | 46.9 | ||||
| Depth | 0.026 | 0.260 | 0.072–0.941 | 0.040 | |||
| Superficial | 11 | 54.5 | 43.6 | ||||
| Deep | 22 | 95.2 | 71.4 | ||||
| Tumor size (cm) (N = 30) | 0.425 | ||||||
| ≤5 | 20 | 75 | 60.0 | ||||
| >5 | 10 | 88.9 | 71.1 | ||||
| Stage (N = 30) | 0.168 | ||||||
| II | 18 | 88.9 | 72.7 | ||||
| III | 12 | 64.8 | 48.6 | ||||
| N0/N1 | 0.005 | 5.714 | 1.436–22.739 | 0.013 | |||
| N0 | 27 | 92.6 | 69.4 | ||||
| N1 | 6 | 33.3 | NA | ||||
| Morphological subtype | 0.052 | ||||||
| Classic type | 23 | 91.3 | 70.2 | ||||
| Proximal type | 10 | 58.3 | 43.8 | ||||
| FNCLCC grade | 0.265 | ||||||
| 2 | 27 | 85 | 66.8 | ||||
| 3 | 6 | 66.7 | 44.4 | ||||
| Surgical margin (N = 32) | 0.036 | NS | |||||
| Negative | 24 | 87.5 | 74.0 | ||||
| Positive | 8 | 62.5 | 31.3 | ||||
| Adjuvant radiotherapy | 0.547 | ||||||
| Done | 6 | 83.3 | 83.3 | ||||
| Not done | 27 | 81.3 | 59.6 | ||||
| Adjuvant chemotherapy | 0.201 | ||||||
| Done | 3 | 100 | 100 | ||||
| Not done | 30 | 79.7 | 57.0 | ||||
NS not significant, HR hazard ratios, 95 % CI 95 % confidence interval