Table 3.
Univariate and multivariate analysis of factors influencing distant metastases-free survival in 33 patients with M0 tumors
| Variable | No. of cases | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| 2-year DMFS rate | 5-year DMFS rate | p Value | HR | 95 % CI | p Value | ||
| Sex | 0.321 | ||||||
| Male | 24 | 42.6 | 37.3 | ||||
| Female | 9 | 77.8 | 31.1 | ||||
| Age at presentation, years | 0.847 | ||||||
| ≤30 | 11 | 45.5 | 34.1 | ||||
| >30 | 22 | 61.8 | 34.6 | ||||
| Location | 0.972 | ||||||
| Distal | 18 | 54.5 | 29.2 | ||||
| Proximal | 15 | 58.2 | 41.6 | ||||
| Depth | 0.906 | ||||||
| Superficial | 11 | 45.5 | 36.4 | ||||
| Deep | 22 | 61.2 | 32.6 | ||||
| Tumor size (cm) (N = 30) | 0.708 | ||||||
| ≤5 | 20 | 50.0 | 31.2 | ||||
| >5 | 10 | 56.3 | 42.2 | ||||
| Stage (N = 30) | 0.255 | ||||||
| II | 18 | 55.6 | 41.7 | ||||
| III | 12 | 46.9 | 23.4 | ||||
| N0/N1 | 0.003 | 4.101 | 1.508–11.155 | 0.006 | |||
| N0 | 27 | 64.9 | 43.7 | ||||
| N1 | 6 | 16.7 | 0 | ||||
| Morphological subtype | 0.937 | ||||||
| Classic type | 23 | 55.2 | 29.4 | ||||
| Proximal type | 10 | 57.1 | 45.7 | ||||
| FNCLCC grade | 0.296 | ||||||
| 2 | 27 | 61.3 | 39.4 | ||||
| 3 | 6 | 33.3 | 16.7 | ||||
| Surgical margin (N = 32) | 0.231 | ||||||
| Negative | 24 | 56.7 | 45.4 | ||||
| Positive | 8 | 50.0 | 12.5 | ||||
| Adjuvant radiotherapy | 0.769 | ||||||
| Done | 6 | 57.8 | 32.1 | ||||
| Not done | 27 | 50.0 | 50.0 | ||||
| Adjuvant chemotherapy | 0.239 | ||||||
| Done | 3 | 54.8 | 31.3 | ||||
| Not done | 30 | 66.7 | 66.7 | ||||
| Local recurrence | 0.149 | ||||||
| Not occurred | 23 | 53.7 | 53.7 | ||||
| Occurred | 10 | 60.0 | 10.0 | ||||
NS not significant, HR hazard ratios, 95 % CI 95 % confidence interval