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. 2015 Jul 31;5:12671. doi: 10.1038/srep12671

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Copyright © 2015, Macmillan Publishers Limited

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Curcumin, AE and AC treatments were given beyond 12 h after the onset of symptoms (day 8 or 9 post infection) but before the coma stage. (a) Effect of drug treatments on survival of mice. AE was used at different sub-optimal concentrations ranging from 250 μg to 650 μg and given as a single injection. Curcumin was given in 3 oral doses. Survival curve analysis was carried out by Kaplan-Meier plot and P values calculated by Log-rank (Mantel-Cox) test. The experiment was carried out with 5 animals in each group and the experiment repeated twice. (b) Parasitemia in blood of the drug treated animals. (c) RT-PCR analysis of parasite 18S rRNA, CXCL10 and TNFα in the brain in the early stage after the drug treatments (day 12, AE 650 μg). The experiment was repeated twice and the data represent mean ± SD from five animals in each group.