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. 2015 Jul 31;5:12519. doi: 10.1038/srep12519

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Average EEG activity recorded during (A) background, (B) in response to non-noxious control stimulation, and (C) following noxious heel lance in 6 infants. The nociceptive-specific principal component (PC) is overlaid in red. The PC weights were significantly greater (*p < 0.05) in response to lance than background and control (D). Error bars indicate standard error of the mean.