Table 3. Circulating concentrations of fasting blood glucose, lipid profiles, and bone metabolic markers in db/db mice.
Variables | WT | db/db | Etomoxir | MitoQ | PFT-α |
---|---|---|---|---|---|
FBG (mmol/L) | 4.6 ± 0.8 | 21.5 ± 3.8* | 20.6 ± 4.2 | 15.3 ± 2.7# | 22.1 ± 3.9 |
FFA (mmol/L) | 0.57 ± 0.12 | 1.23 ± 0.15* | 1.26 ± 0.11 | 0.87 ± 0.16# | 1.11 ± 0.17 |
TG (mmol/L) | 1.23 ± 0.22 | 3.16 ± 0.48* | 3.37 ± 0.56 | 2.39 ± 0.26# | 3.08 ± 0.39 |
HDL (mmol/L) | 1.83 ± 0.21 | 1.35 ± 0.17* | 1.31 ± 0.16 | 1.58 ± 0.15# | 1.36 ± 0.23 |
LDL (mmol/L) | 0.86 ± 0.15 | 1.74 ± 0.16* | 1.77 ± 0.18 | 1.12 ± 0.24# | 1.69 ± 0.29 |
ALP (U/L) | 132 ± 17 | 61 ± 18* | 95 ± 11# | 113 ± 13# | 109 ± 14# |
Osteocalcin (ng/mL) | 93 ± 15 | 75 ± 8* | 86 ± 3# | 90 ± 5# | 88 ± 6# |
TRAP (U/L) | 6.1 ± 1.2 | 12.5 ± 2.3* | 8.6 ± 1.3# | 7.4 ± 1.8# | 7.9 ± 2.4# |
All values were shown as means ± SD.
*p < 0.05, compared with WT.
#p < 0.05, compared with db/db mice.