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. 2014 Dec 15;2(4):253–258. doi: 10.14218/JCTH.2014.00020

Table 1. Summary of several related-microRNAs in hepatocellular carcinoma and their biological roles.

miRs Targets Biological roles References
miR-AFP AFP, beclin-1 Proliferation, apoptosis Peng FL, et al. (2013)
miR-HIF-1α HIF-1α Angiogenesis, proliferation Wang L, et al. (2013)
miR-GPC-3 GPC-3, Wnt/β- catenin Angiogenesis, metastasis, proliferation Chen J, et al. (2013)
miR-1 ET1 Proliferation Li D, et al. (2012)
miRs-7 Caspase-3, HMGA2, C-myc, Bcl-xl Proliferation, apoptosis Ji J, et al. (2010)
miR-IGF-II IGF-II/IGF-IR pathway Proliferation, angiogenesis, apoptosis Yao NH, et al. (2012)
miR-101 Mcl-1, SOX-9, EZH2, EED, DNMT3A Proliferation, apoptosis Tsai WC, et al. (2009)
miRs-122 Bcl-w, ADAM-1, Wnt-1 Angiogenesis, apoptosis, metastasis Xu J , et al. (2012)
miR-125a, -125b MMP11, SIRT7, VEGF-A, LIN28B2, Bcl Angiogenesis, metastasis, proliferation Kim JK, et al. (2013)
miR-139 c-Fos, Rho-kinase-2 Metastasis Wong CC, et al. (2011)
miR-145 IRS1-2, OCT4, IGF pathway Stem-like cells tumorigenicity Jia Y, et al. (2012)
miR-195 CDK6, E2F3, cyclinD1 Proliferation, apoptosis, tumorigenicity Yang X, et al. (2012)
miR-199a-3p, -199-5p c-Met, mTOR, PAK4, DDR1, caveolin-2 Proliferation, autophagy, metastasis Huh J, et al. (2011)
miRs-214 HDGF, β-catenin Proliferation, angiogenesis, metastasis Xia H, et al. (2012)
miR-10a EphA4, CADM1 EMT metastasis Li QJ, et al. (2012)
miR-21 Pten, RhoB, PDCD4 Drug Resistance, metastasis Meng F, et al. (2007)
miR-221 Bmf, DDIT4, Arnt, CDKN1B/p27 or1C/p57 Angiogenesis, apoptosis, proliferation Yuan Q, et al. (2013)
miRs-224 Yin Yang1/Raf-1 kinase, NF-kB, apoptosis inhibitor-5 Proliferation, apoptosis, metastasis Wang Y, et al. (2008)