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. 2014 Jun 15;2(2):95–102. doi: 10.14218/JCTH.2014.00011

Table 1. Chemotherapy drugs and liver side effects.

Drug Hepatitis Cholestasis Biliary Stricture Steatosis Nodular Hyperplasia Fibrosis Veno-Occlusive Disease
Actinomycin Rare Rare
Arsenic
Asparaginase Common Common
Azathioprine Rare Rare
Bleomycin Rare
Bortezomib Rare
Busulfan Rare Rare Rare
Capecitabine Rare
Carmustine Common
Chlorambucil Rare
Cyclophosphamide Rare Common
Cytarabine Rare Common
Dacarbazine Rare
Docetaxel Rare
Doxorubicin Rare Rare Rare
Erlotinib Common
Etoposide Rare Rare
Floxuridine Common Common Common
Fluorouracil Rare Common Rare
Gefitinib Rare
Gemcitabine Rare Rare
Hydroxyurea Rare
Ifosfamide Rare
Imatinib Common
Interferon Common
Interleukin Common
Irinotecan Rare
Lomustine Rare
Melphalan Rare Rare
Mercaptopurine Rare Rare
Methotrexate Common Common
Mitomycin Rare Rare
Oxaliplatin Rare Rare Common
Paclitaxel Rare
Pazopanib Common
Procarbazine Rare
Regorafenib Rare
Sorafenib Rare Rare
Streptozocin Rare
Thioguanine Rare Rare
Topotecan Rare
Vincristine Rare
Vinorelbine Rare