Table 1. IL-22-producing cells and transcription factors.
Cell subset | Stimulating cytokines | Transcription factor |
Th17 cells | IL-6 | AHR |
Th22 cells | IL-6 and TNFα | AHR |
γδT cells | IL-23 | AHR |
NK cells | IL-12 and IL-18 or IL-23 | RORγt |
RORγt-positive ILCs | Il-23 | RORγt |