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. 2013 Dec 15;1(2):79–86. doi: 10.14218/JCTH.2013.00015

Table 1. Review of major literature on the use of budesonide in AIH.

Author Year No. of Patients Budesonide Dose Study End Points Results
Danielsson 1994 13 6–8 mg daily Decrease in ALT, AST, IgG Complete response: 100%
Zandieh 2008 9 3 mg every other day to 9 mg daily Complete response: Normal ALT, AST Complete response: 78% No response: 22%
Wiegand 2005 12 Day 1: 6 mg daily Day 2: 9 mg daily Upon remission: 6 mg daily Complete remission: AST and ALT drop ≤ two times the upper limit of normal Partial response: ALT or AST ≤ two times the upper limit of normal or AST/ALT improvement > 80% from baseline Complete response: 58% Partial response: 25%
Csepregi 2006 11 9 mg daily Remission: Absence of symptoms Normal ALT, ALP, IgG Treatment-naïve: 57% Treatment-experienced: 100%
Manns 2010 203 (100 received Budesonide and 103 received prednisone) 6 mg daily or 9 mg daily Complete response: Normal ALT Normal AST Absence of steroid-related side effects Budesonide group: 47% Prednisone group: 18.4%
Czaja 2000 10 9 mg daily Remission: Asymptomatic Normal or near normal AST Normal bilirubin Normal γ-globulin Failure: Clinical/biochemical deterioration Remission: 30%Treatment failure: 40%