Figure 2.

Frequency of each clinical manifestation in patients with Japanese FAD and FTDP-17. We investigated the presence or absence of psychiatric symptoms, mood disorders, spastic paraplegia, parkinsonism and epilepsy/seizure by careful reading of the original papers. We determined the frequency of each of the clinical manifestations by counting the number of patients for whom the presence of the manifestation was described in literature. In case there was no description of the manifestation, the patient was not counted as manifesting the manifestation. The observed frequencies of causative gene mutation were significantly different from the expected frequencies determined by residual analyses for χ² statistical analysis (*P<0.05, **P<0.01). FAD, familial Alzheimer's disease; FTDP-17, frontotemporal dementia with parkinsonism linked to chromosome 17.