Table 3.
Drugs and drug combinations most frequently involved in DDIs
| Detecting CDSS (interactions in total) | Drug combinations | % | Drugs | % | |
|---|---|---|---|---|---|
| AU (261) | Severe (3.8 %) | ASS-Ibuprofen | 80 | ASS | 40 |
| Melperone-Ropinirole | 10 | Ibuprofen | 40 | ||
| Levofloxacin-Amitriptyline | 10 | Levofloxacin | 5 | ||
| Amitriptyline | 5 | ||||
| Ropinirole | 5 | ||||
| Melperone | 5 | ||||
| Severe/Considerable (36.3 %) | Tramadol-Pregabalin | 3.1 | Pregablin | 8.4 | |
| Amitriptyline-Tramadol | 3.1 | Ibuprofen | 7.8 | ||
| Ibuprofen-Enalapril | 3.1 | Amitriptyline | 7.3 | ||
| Pregabalin-Morphine | 3.1 | ||||
| Significant (rare) (37.9 %) | Ramipril-HCT | 3 | ASS | 9.6 | |
| Pantoprazole-ASS | 3 | HCT | 8.5 | ||
| ASS-Olmesartan | 3 | Ibuprofen | 6 | ||
| Metformin-ASS | 3 | ||||
| Slight (16.4 %) | ASS-Amlodipine | 14.9 | ASS | 32.5 | |
| ASS-Ramipril | 11.6 | Amlodipine | 8.1 | ||
| ASS-Bisoprolol | 9.3 | Thyroxine | 8.1 | ||
| ASS-Metoprolol | 9.3 | ||||
| Not relevant (5.3 %) | Pantoprazole-Diclofenac | 21.4 | Pantoprazole | 21.4 | |
| Pantoprazole-Duloxetine | 21.4 | Diclofenac | 10.7 | ||
| Carbamazepine | 10.7 | ||||
| Duloxetine | 10.7 | ||||
| MS (178) | Severe (6.7 %) | ASS-Ibuprofen | 50 | ASS | 25 |
| Telmisartan-Ramipril | 16.6 | Ibuprofen | 25 | ||
| Significant (75.2 %) | ASS-Ibuprofen | 8.2 | ASS | 17.5 | |
| Ibuprofen-Diclofenac | 7.5 | Ibuprofen | 16.8 | ||
| Minor Significant (17.9 %) | ASS-Ibuprofen | 18.7 | Ibuprofen | 21.8 | |
| Diclofenac-Ibuprofen | 15.6 | ASS | 18.7 | ||
| AID (170) | Severe (11.7 %) | Ibuprofen-ASS | 40 | Ibuprofen | 25 |
| Amitriptyline-Tramadol | 15 | ASS | 20 | ||
| Trimipramine-Tramadol | 10 | Tramadol | 12.5 | ||
| Potentially clinically relevant (42.9 %) | Ramipril-ASS | 6.8 | ASS | 11.6 | |
| HCT-Ramipril | 4.1 | Ramipril | 8.9 | ||
| Enalapril-Ibuprofen | 4.1 | HCT | 8.2 | ||
| Pregabalin-Oxycodone | 4.1 | ||||
CDSS Cinical decision suport sytem, AID CDSS AiDKlinik®, AU CDSS Apotheken Umschau, MS CDSS Medscape, HCT Hydrochlorothiazide, ASS Acetylsalicylic acid