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Histograms of fold-critical over remnant E-value ratios for the negative HMMER2 and HMMER3 hits respectively. Given the ratio between fold-critical versus remnant E-values of 0.056 (10–2.25), the corresponding FPR for HMMER2 is found to be about 0.1 (see dotted line in Fig. 11a). Correspondingly for the same FPR (see dotted line in Fig. 11b, this ratio for HMMER3 is preset at a much smaller value of 7.9e–10 (10−9.1)
