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Histograms of fold-critical E-values for the negative HMMER2 and HMMER3 hits respectively. At a fold-critical E-value of 3.6e–4 (10−3.45), the FPR is found to be approximately 0.1 (see dotted line) for HMMER2 in Fig. 12a. Meanwhile, the fold-critical E-value is set at 1.0e–6 (10−6) for the same FPR for HMMER3 based on Fig. 12b (see dotted line)
