Table 1.
Summary of Gene Ontology Analysis of differentially expressed gene lists. The analysis is based on D. melanogaster orthologs matching honey bee genes that were significantly differentially expressed between treatment groups. Only GO terms and KEGG pathways that were significantly overrepresented (medium stringency, P-value < 0.05) are shown in the table. Benjamini corrections for multiple testing are provided alongside corresponding P-values
| Category | Term | Genes | P-Value | Benjamini | |
|---|---|---|---|---|---|
| mated vs. virgin | carbohydrate metabolic process | 30 | 3.33E-05 | 0.022 | |
| organic acid metabolic process | 27 | 1.79E-04 | 0.076 | ||
| amine metabolic process | 26 | 1.00E-03 | 0.209 | ||
| defense response | 11 | 0.009 | 0.778 | ||
| sensory perception | 15 | 0.011 | 0.782 | ||
| melanization defense response | 3 | 0.012 | 0.764 | ||
| biological process | cellular amino acid metabolic process | 16 | 0.015 | 0.76 | |
| fatty acid metabolic process | 7 | 0.015 | 0.737 | ||
| innate immune response | 7 | 0.015 | 0.737 | ||
| carbohydrate catabolic process | 8 | 0.017 | 0.752 | ||
| tissue development | 30 | 0.026 | 0.805 | ||
| detection of stimulus | 8 | 0.04 | 0.805 | ||
| sodium ion transport | 6 | 0.041 | 0.794 | ||
| cellular component | myofibril | 5 | 0.002 | 0.035 | |
| membrane part | 81 | 0.003 | 0.046 | ||
| proteinaceous extracellular matrix | 7 | 0.006 | 0.071 | ||
| plasma membrane | 39 | 0.009 | 0.093 | ||
| cofactor binding | 19 | 7.91E-05 | 0.022 | ||
| monooxygenase activity | 12 | 0.002 | 0.151 | ||
| lipase activity | 10 | 0.004 | 0.214 | ||
| FAD binding | 8 | 0.005 | 0.227 | ||
| vitamin binding | 10 | 0.008 | 0.259 | ||
| molecular function | sugar transmembrane transporter activity | 5 | 0.014 | 0.29 | |
| transcription factor activity | 23 | 0.018 | 0.325 | ||
| receptor activity | 27 | 0.018 | 0.318 | ||
| transforming growth beta receptor binding | 3 | 0.023 | 0.336 | ||
| identical protein binding | 11 | 0.03 | 0.368 | ||
| sulfate transmembrane transporter activity | 3 | 0.037 | 0.424 | ||
| metabolic pathways | Starch and sucrose metabolism | 7 | 0.003 | 0.081 | |
| Glycolysis / Gluconeogenesis | 7 | 0.004 | 0.061 | ||
| Retinol metabolism | 5 | 0.006 | 0.058 | ||
| Arginine and proline metabolism | 7 | 0.006 | 0.051 | ||
| beta-Alanine metabolism | 5 | 0.013 | 0.087 | ||
| Lysine ddegradation | 5 | 0.05 | 0.192 | ||
| mated vs. CO2 | biological processes | aromatic amino acid family process | 5 | 0.003 | 0.757 |
| sensory perception | 11 | 0.024 | 0.995 | ||
| monocarboxylic acid metabolic process | 7 | 0.031 | 0.992 | ||
| tissue development | 22 | 0.032 | 0.987 | ||
| response to organic substance | 8 | 0.044 | 0.992 | ||
| cellular component | membrane | 70 | 1.00E-03 | 0.014 | |
| muscle myosin complex | 3 | 0.004 | 0.053 | ||
| extracellular region part | 8 | 0.032 | 0.255 | ||
| molecular function | sugar transmembrane transporter activity | 5 | 0.006 | 0.222 | |
| transporter activity | 33 | 0.007 | 0.246 | ||
| retinal binding | 3 | 0.018 | 0.394 | ||
| lipase activity | 6 | 0.033 | 0.545 | ||
| olfactory receptor activity | 5 | 0.037 | 0.551 | ||
| CO2 vs. virgin | biological process | cognition | 7 | 0.004 | 0.105 |
| cellular component | rhabdomere | 4 | 1.00E-03 | 0.01 | |
| membrane | 21 | 0.001 | 0.012 | ||
| cell projection | 5 | 0.004 | 0.039 | ||
| integral to membrane | 12 | 0.056 | 0.333 | ||
| molecular function | monooxygenase activity | 5 | 3.09E-04 | 0.054 |