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. 2015 Jul 31;10:159. doi: 10.1186/s13014-015-0465-x

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© Prokopiou et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — In silico comparison of altered fractionation regimes using parameters estimated for NSCLC patients. a Model predicted improvement in tumor volume reduction when comparing (1.2 Gy x 58; b.i.d. 9 am and 3 pm; BED=73.8 Gy) RTOG phase III hyperfractionation [36] to the standard of care (2 Gy x 30; q.d. 9 am; BED=66 Gy) as a function of proliferation saturation index (PSI). Red line at 5 % indicates statistical significance. b Model predicted improved tumor volume reduction when comparing (1.2 Gy x 58; b.i.d. 9 am and 3 pm) hyperfractionation to the daily doses with equal BED (2.21 Gy x 30; q.d. 9 am; BED=73.8 Gy) as a function of proliferation saturation index (PSI)