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. Author manuscript; available in PMC: 2015 Jul 31.
Published in final edited form as: Cell Rep. 2015 Jul 16;12(4):599–609. doi: 10.1016/j.celrep.2015.06.054

Figure 6. AMPK phosphorylates GLI1 and inhibits Hedgehog pathway.

Figure 6

The diagram shows that activated AMPK directly phosphorylates GLI1 on S102, S408, and T1074 sites. Phosphorylation lowers GLI1 protein stability, thus reducing GLI1 transcriptional activity and mitigates cell growth.