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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Future Med Chem. 2015 Jun;7(8):1023–1038. doi: 10.4155/fmc.15.44

Figure 6. Interactions of HIV protease with P2 group of darunavir and selected inhibitors.

Figure 6

The interactions of the P2 bis-THF group of darunavir with protease residues Asp29, Asp30, Gly27 and Gly48, and the same view of the P2 interactions of antiviral inhibitors GRL-0519, GRL-04410 and GRL-05010. The PDB ID is shown for each structure. Water molecules are shown as spheres. Hydrogen bond interactions are indicated by dotted lines.