. Author manuscript; available in PMC: 2015 Jul 31.

Published in final edited form as: Crit Rev Toxicol. 2015 Jan;45(1):1–43. doi: 10.3109/10408444.2014.973934

Table 4.

Organs in which benzo(a)pyrene significantly (at least two doses) and dose-dependently increased tumor incidence (number of tumor-bearing animals/number of total animals is presented).

Study	Species, sex	BaP dose		Daily intake (mg/kg bw per day)	Forestomach			Liver

		Diet (ppm)	Gavage (mg/kg bw per day)		Papillomas and/or carcinomas	Papillomas	Carcinomas	Adenomas and/or carcinomas	Adenomas	Carcinomas
Culp et al. (1998)	Female mice	0		0^*	1/48
		5		0.65^*	3/47
		25		3.5^*	36/46^‡
		100		15.2^*	46/47^‡

Wester et al. (2012)	Male rats		0	0^§	0/52	0/52	0/52	0/52	0/52	0/52
			3	2.14^§	8/52^‡	7/52^‡	1/52	4/52	3/52	1/52
			10	7.14^§	43/52^‡	18/52^‡	25/52^‡	38/52^‡	15/52^‡	23/52^‡
			30	21.43^§	52/52^‡	17/52^‡	35/52^‡	49/52^‡	4/52	45/52^‡
	Female rats		0	0^§	1/52	1/52	0/52	0/52	0/52	0/52
			3	2.14^§	6/51	3/51	3/51	2/52	2/52	0/52
			10	7.14^§	30/51^‡	20/51^‡	10/51^‡	39/52^‡	7/52^‡	32/52^‡
			30	21.43^§	50/52^‡	25/52^‡	25/52^‡	51/52^‡	1/52	50/52^‡

Calculated daily intake, corrected for food consumption (Cal/EPA (2010) calculation based on food consumption and body weight).

† Reported by Schneider et al. (2002).

^‡

Significantly different from control (p < 0.05) as reported in Benford et al. (2010) or in Cal/EPA (2010).

^§

Administered dose of 5 days per week was adjusted to 7 days per week daily dose (dose × 5/7).