TABLE 3.
Univariable and multivariable analysis of factors associated with overall survival in patients with colorectal HGNEC
| Factors | Univariable |
Multivariable |
|||
|---|---|---|---|---|---|
| Median OS (months) | p value | Hazard ratio | 95 % CI | p value | |
| Sex | |||||
| Male | 10.6 | 0.16 | 0.66 | 0.42–1.02 | 0.64 |
| Female | 14.7 | ||||
| Age (years) | |||||
| <56 | 13.6 | 0.99 | 1.002 | 0.99–1.02 | 0.83 |
| ≥56 | 11.1 | ||||
| Site of tumor | |||||
| Colon | 10.8 | 0.54 | 0.81 | 0.49–1.31 | 0.39 |
| Rectum | 15.1 | ||||
| Metastases | |||||
| Yes | 10 | <0.001* | 0.37 | 0.20–0.67 | 0.001* |
| No | 24 | ||||
| Adenocarcinoma component | |||||
| Yes | 13.3 | 0.07 | 1.90 | 1.02–3.53 | 0.04* |
| No | 13.5 | ||||
| Resection of primary tumor | |||||
| Yes | 15 | 0.01* | 1.21 | 0.71–2.05 | 0.49 |
| No | 12 | ||||
| Inflammatory bowel disease | |||||
| Yes | 24.1 | 0.04* | 2.54 | 0.59–11.0 | 0.21 |
| No | 19.8 | ||||
| Radiotherapy (rectal only) | |||||
| Yes | 15.1 | 0.66 | |||
| No | 15.6 | ||||
| Histological types | |||||
| SCC | 14.8 | 0.88 | |||
| LCC | 9.5 | ||||
| Site of metastasis | |||||
| Liver | 9.2 | 0.47 | |||
| Lymph node | 12.9 | ||||
| Other | 9.4 | ||||
| Multiple sites of metastasis | |||||
| Yes | 8.3 | 0.11 | |||
| No | 12.9 | ||||
HGNEC high-grade neuroendocrine carcinoma, OS overall survival, CI confidence interval, LCC large cell carcinoma, SCC small cell carcinoma, LN lymph node
*
Statistical significance