Table 4. Pharmacokinetic parameter medians for topotecan.

Dose level	Daily dose, mg/m2	Cmax, μmol/L (range)		T1/2, h (range)		Cl, L/h/m2 (range)		Vdss, L/m2 (range)		AUC, μmol/L × h (range)
		Total	Lactone	Total	Lactone	Total	Lactone	Total	Lactone	Total	Lactone
1	3.3	0.18	0.18	2.7	2.6	12.97	27.95	49.2	56.6	0.56	0.26
n = 4		(0.14–0.26)	(0.14–0.20)	(1.7–5.1)	(0.6–4.8)	(11.50–21.67)	(21.28–63.95)	(31.1–72.4)	(28.8–81.6)	(0.33–0.63)	(0.11–0.34)
2	5.0	0.21	0.20	3.0	2.7	15.44	41.19	66.8	111	0.65	0.27
n = 6		(0.13–0.75)	(0.09–0.68)	(2.0–9.9)	(1.5–5.1)	(10.12–26.17)	(29.27–46.04)	(33.8–118)	(39.6–183)	(0.42–0.87)	(0.24–0.37)
3	6.8	0. 33	0.23	2.6	3.4	17.14	39.59	57.5	113	0.86	0.38
n = 4		(0.25–0.43)	(0.15–0.43)	(2.0–3.4)	(2.0–8.9)	(9.32–21.50)	(28.07–49.01)	(43.1–74.5)	(81.9–302)	(0.68–1.57)	(0.30–0.52)
4	8.9	0.52	0.48	3.3	3.1	12.05	28.1	53.7	91.6	1.63	0.70
n = 5		(0.34–1.1)	(0.34–0.89)	(2.9–4.2)	(2.6–4.0)	(10.14–23.96)	(25.61–46.73)	(39.1–79.7)	(67.9–120)	(0.82–1.93)	(0.42–0.77)
5	12.0	0.65	0.61	2.9	3.2	16.43	30.11	53.3	94.4	1.86	0.88
n = 9		(0.42–1.21)	(0.30–1.12)	(1.7–10.7)	(1.8–7.2)	(5.85–20.45)	(18.06–40.77)	(35.8–96.8)	(48.7–168)	(1.28–4.47)	(0.64–1.45)
6	15.7	0.87	0.80	3.1	3.3	12.62	23.53	48.1	76.6	2.77	1.48
n = 5		(0.84–1.47)	(0.63–1.46)	(2.3–4.1)	(2.0–3.9)	(9.61–16.90)	(20.38–34.04)	(34.5–65.7)	(54.3–114)	(2.07–3.64)	(1.03–1.71)
7	21.3	1.08	0.92	2.6	2.7	13.43	29.10	63.9	95.8	3.47	1.60
n = 7		(0.83–4.17)	(0.57–4.06)	(2.1–6.3)	(1.9–7.0)	(7.93–17.79)	(14.47–35.17)	(36.2–98.1)	(48.4–199)	(2.62–5.87)	(1.32–3.22)
8	28.4	2.12	1.67	2.4	2.3	10.78	25.77	41.1	81.5	5.73	2.40
n = 5		(1.32–3.03)	(1.21–2.70)	(2.0–5.8)	(2.1–4.4)	(6.20–12.34)	(20.39–27.85)	(38.3–64.0)	(41.2–107)	(5.02–9.98)	(2.22–3.03)

Note. Daily dose was given each day for 3 days.

Abbreviations: Cl, clearance; C_max, maximal concentration; T_1/2, half life; V_dss, volume of distribution.