Table 2.

The 20 most commonly endorsed items on the Sickness Impact Profile (SIP) by (A) all patients, (B) those with cataplexy, and (C) those with HLA DQB1⁎0602 positivity.

(A) Among all patients (n=226)
Itema	Weight	Dysfunctional behavior	Percent
sr7	60	I sleep or nap more during the day	46
rp2	36	I am going out for entertainment less often	43
hm2	44	I am doing less of the regular daily work around the house than I would usually do	39
si9	51	My sexual activity is decreased	39
rp1	39	I do my hobbies and recreation for shorter periods of time	39
si6	36	I am doing fewer social activities with groups of people	37
ab4	67	I do not finish things I start	37
ab7	78	I forget a lot, for example, things that happened recently, where I put things, appointments	37
sr6	61	I sleep less at night, for example, wake up too early, don’t fall asleep for a long time, awaken frequently	35
hm1	54	I do work around the house only for short periods of time or rest often	35
sr5	84	I sit around half-asleep	33
sr2	49	I sit during much of the day	29
si1	44	I am going out less to visit people	28
a1	48	I walk shorter distances or stop to rest often	28
ab10	80	I have difficulty doing activities involving concentration and thinking	28
rp7	43	I am cutting down on some of my usual physical recreation or activities	28
sr4	58	I lie down more often during the day in order to rest	27
rp6	33	I am doing fewer community activities	26
ab8	67	I do not keep my attention on any activity for long	23
bcm12	30	I change position frequently	22

(B) Among patients with cataplexy (n=152)
Itema	Weight	Dysfunctional behavior	Percent
si6	36	I am doing fewer social activities with groups of people	44
rp2	36	I am going out for entertainment less often	44
sr6	61	I sleep less at night, for example, wake up too early, don׳t fall asleep for a long time, awaken frequently	43
sr7	60	I sleep or nap more during the day	43
ab7	78	I forget a lot, for example, things that happened recently, where I put things, appointments	43
hm2	44	I am doing less of the regular daily work around the house than I would usually do	42
si9	51	My sexual activity is decreased	41
rp1	39	I do my hobbies and recreation for shorter periods of time	41
hm1	54	I do work around the house only for short periods of time or rest often	39
ab4	67	I do not finish things I start	39
sr2	49	I sit during much of the day	36
sr5	84	I sit around half-asleep	36
rp7	43	I am cutting down on some of my usual physical recreation or activities	35
si1	44	I am going out less to visit people	34
ab10	80	I have difficulty doing activities involving concentration and thinking	34
a1	48	I walk shorter distances or stop to rest often	31
rp6	33	I am doing fewer community activities	31
ab8	67	I do not keep my attention on any activity for long	30
bcm12	30	I change position frequently	28
ab2	75	I have more minor accidents, for example, drop things, trip and fall, bump into things	27

(C) Among patients with HLA DQB1⁎0602 positivity (n=113)
Itema	Weight	Dysfunctional behavior	Percent
sr7	60	I sleep or nap more during the day	44
rp2	36	I am going out for entertainment less often	40
si9	51	My sexual activity is decreased	39
hm2	44	I am doing less of the regular daily work around the house than I would usually do	38
rp1	39	I do my hobbies and recreation for shorter periods of time	37
si6	36	I am doing fewer social activities with groups of people	36
sr6	61	I sleep less at night, for example, wake up too early, don’t fall asleep for a long time, awaken frequently	35
hm1	54	I do work around the house only for short periods of time or rest often	35
ab4	67	I do not finish things I start	34
ab7	78	I forget a lot, for example, things that happened recently, where I put things, appointments	32
sr2	49	I sit during much of the day	31
sr5	84	I sit around half-asleep	29
sr4	58	I lie down more often during the day in order to rest	27
si1	44	I am going out less to visit people	27
a1	48	I walk shorter distances or stop to rest often	27
ab10	80	I have difficulty doing activities involving concentration and thinking	26
rp7	43	I am cutting down on some of my usual physical recreation or activities	26
rp6	33	I am doing fewer community activities	25
bcm12	30	I change position frequently	22
rp3	59	I am cutting down on some of my usual inactive recreation and pastimes, for example, watching TV, playing cards, reading	21

^aThe SIP items describe dysfunctional behavior endorsed by patient with narcolepsy. Each item has a weight reflecting the relative severity of the dysfunction compared to other items. The percent of patients endorsing an item out of all the patients is given in the final column. The letters stand for categories (see Figs. 1 and 2 and Table 3), and the number represents an item in the category.