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. 2015 Jul 24;8:1877–1885. doi: 10.2147/OTT.S78404

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© 2015 Huang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effects of test compounds on GST-catalyzed GSH conjugation in the presence of GSTA1. IC₅₀ values for inhibition of formation of the CDNB–GSH conjugate for ethacrynic acid =1.1 μM (5 μM) and FBuEA =17.5 μM.

Abbreviations: CDNB, chlorodinitrobenzene; FBuEA, fluorobutyl ethacrynic amide; GSH, glutathione; GST, glutathione transferase; GSTA1, glutathione S-transferase alpha-1; IC₅₀, half maximal inhibitory concentration.