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. 2015 Jul 31;9(7):e0003965. doi: 10.1371/journal.pntd.0003965

Fig 5. Temporal serum levels of parasite-derived miRNAs in C57BL/6 and BALB/c mice at different time points and their correlations with hepatic egg burdens.

Fig 5

The serum levels of sja-miR-277 and sja-miR-3479-3p in C57BL/6 (A and B) and BALB/c (C and D) mice, respectively, during the course of infection. MiRNAs were quantified by qRT-PCR and normalised to the spiked ath-miR-159a; fold changes are defined as the ratio of miRNA abundance in the serum of infected mice compared with the background level in the serum of naive mice. Statistical differences between infected and naive mice were determined using the Man-Whitney test (ns = no significant difference, ** = P<0.01, *** = P<0.001, **** = P<0.0001). Correlations between the serum level of sja-miR-277/sja-miR3479-3p and hepatic egg burden (E and F), as well as the degree of hepatic fibrosis (G and H) were performed for both mouse strains.