Table 1. Summary of key findings comparing C57BL/6 and BALB/c mice during S. japonicum infection.
| C57BL/6 | BALB/c | |
|---|---|---|
| Serum chemistry | ||
| Changes in serum AST level | + | ++++ |
| Changes in serum ALT level | ++ | ++++ |
| Hepatic histology | ||
| Hepatic granuloma | +++ | + |
| Hepatic fibrosis | +++ | + |
| Hepatic necrosis | + | ++ |
| Host circulating miRNAs | ||
| Changes in serum mmu-miR-122 level | - | +++ |
| Changes in serum mmu-miR-21 level | + | +++ |
| Changes in serum mmu-miR-20a level | - | - |
| Changes of serum mmu-miR-34a level | - | +++ |
| Parasite-derived miRNAs | ||
| Changes in serum sja-miR-277 level | ++, 6 weeks p.i.* | +++, 4 weeks p.i.* |
| Changes in serum sja-miR-3479-3p level | +, 9 weeks p.i.* | ++, 6 weeks p.i.* |
* The time point when the circulating miRNA started to show a significantly different level in the S. japonicum-infected mice compared with naïve mice.