Fig 6. Synaptic efficiency and plasticity in the dentate gyrus.

A: Input-output relationship in the DG. Evoked responses were similar in MML of WT and TTS DG (blue and red markers respectively). B: Time course of the averaged initial slope of field EPSPs during the experiment. Tetanization (arrow) evoked stable LTP in WT, but not in TTS mice (blue and red markers respectively). The results are mean ± SEM. The number of slices/mice examined: WT = 9/4; TTS = 8/4. C: Suppression of inhibition by picrotoxin allowed for induction of normal LTP in the TTS slices. The results are mean ± SEM. The number of slices/mice examined: WT = 6/3; TTS = 7/3.