Table 1. Major behavioral and physiological phenotypes in mouse genetic models of Down syndrome.

	TTS	Ts65Dn	Ts1Cje	Ts1Rhr	Dp(10)1Yey	Dp(16)1Yey	Dp(17)1Yey	Ts1Yah	Tc1
The first reference	[43]	[54]	[17]	[18]	[42]	[42]	[42]	[16]	[15]
Added genetic regions /# of genes/
Mmu10	Pdxk-Prmt2/41 genes/				Pdxk-Prmt2/41 genes/
Mmu16	Lipi-Zfp295, /115 genes/	mir155-Zfp295 /100 genes/	Sod1- Zfp295/69 genes/	Cbr1-ORF9/29 genes/		Lipi-Zfp295, /115 genes/		Abcg1–U2af1 /12 genes/
Mmu17	Umodl1-Rrp1b /19 genes/						Umodl1-Rrp1b /19 genes/
Hsa21									~92% of all Hsa21 genes
Body weight	↓[43]☑	↓ [55,56]	↔ [3]	↔[45,57]	─	─	─	─	─
Physical fitness
Grip force	↓ [43]	↓ [58]	─	─	─	─	─	─	↔ [59]
Ambulatory velocity	↓ ☑	↑[25,26,37]	─	↔ [45]	─	─	─	─	↑ [59]
Swimming velocity	↓ [43]	↓[58,60];↔[24]	─	─	↔ [42]	↓[42]	↔ [42]	↔ [16]	─
Locomotor activity
Ambulatory distance	↔ ☑	↑[25,26,37]	─	↔ [45]	─	─	─	↔ [16]	↑ [59]
Ambulatory time	↑ ☑	↑[26,37]	─	─	─	─	─	─	─
Jumps/Jumping time	↓ ☑	↑[25]	─	─	─	─	─	─	─
Vertical time/counts	↔ ☑	↑ [25]	─	↓ [45]	─	─	─	─	─
Other activity tests			↓[17]
Stereotypic and compulsive behavior
Stereotypic	↔ ☑	↑[61,62]	─	─	─	─	─	─	↑ [59]
Compulsive	↓ ☑	─	─	─	─	─	─	─	─
Anxiety
Thigmotactic behav.	↔ ☑	↔[26]; ↑[37]	─	↑ [45]	─	─	─	↔ [16]	↓ [59]
Pellet test	↔ ☑	↔[26]	─	↔ [45]	─	─	─	─	─
Other anxiety tests				↔[63]				↔ [16]	↔ [15]
Working memory
Y-maze	↔ ☑	↓ [25,37]	─	─	─	─	─	↓ [16]	─
T-maze	↓ ☑	↓[25,26]	↓ [3]	↓ [45]	─	─	─	─	↔ [15]
Long-term memory
Morris water maze	↓ [43]	↓[19,20,21,22,23,24]	↓[17,64]	↔[21]	↔[42]	↓[42]	↔ [42]	↑ [16]	↔ [65]
CFC	↓ [43]	↓ [25,27,28]	─	─	↔[42]	↓[42]	↔ [42]	─	─
NOR	↓ ☑	↓ [23,25,26,37,66]	↔ [67]	↓ [45]	─	─	─	─	↔ [65]
Synaptic plasticity
CA1 HFS	─	↓[34];↔[35]	↓[68]	↔[21]	─	─	─	↑ [16]	─
CA1 TBS	↓[43]	↓ [35,36,37]	─	─	↔[42]	↓[42]	↑[42]	─	─
CA1 TBS+GABAA ant	─	↔ [35]	─	─	─	─	─	─	─
DG HFS	↓ ☑	↓[26,30,38]	↓ [3]	↓ [45]	─	─	─	─	↓ [15,65]
DG HFS+GABAA ant.	↔ ☑	↔ [30,38]	↔ [3]	↔ [45]	─	─	─	─	─

‘☑’–Results of this study;

‘↔’—No change;

‘↑’–Increased;

‘↓’—Reduced;

‘─’–Data not published.