Table 1.
Baseline characteristics according to donor status
| All patients (n=2763) | Standard criteria donors (n=1847) | Expanded criteria donors (n=916) | P* | |
|---|---|---|---|---|
| Recipient characteristics | ||||
| Age (years, mean (SD)) | 49.23 (13.51) | 44.26 (12.31) | 59.23 (10.21) | <0.001 |
| Male sex (no (%)) | 1643 (59.5) | 1105 (59.8) | 538 (58.7) | 0.582 |
| Causes of end stage renal disease (no (%)) | ||||
| Glomerulonephritis | 767 (27.8) | 561 (30.4) | 206 (22.5) | <0.001 |
| Diabetes | 264 (9.5) | 171 (9.2) | 93 (10.1) | |
| Hypertension | 212 (7.7) | 129 (7.0) | 83 (9.1) | |
| Other | 1520 (55.0) | 986 (53.4) | 534 (58.3) | |
| Time since onset of dialysis (years, mean (SD)) | 3.90 (4.41) | 3.85 (4.67) | 4.02 (3.84) | 0.3451 |
| Donor characteristics | ||||
| Age (years, mean (SD)) | 50.31 (15.98) | 42.34 (12.51) | 66.37 (8.29) | <0.001 |
| Donor age (years, no (%)) | ||||
| 0-50 | 1222 (44.2) | 1222 (66.2) | 0 | <0.001 |
| 50-60 | 733 (26.6) | 565 (30.6) | 168 (18.3) | |
| ≥60 | 808 (29.2) | 60 (3.2) | 748 (81.7) | |
| Male sex (no (%)) | 1509 (54.6) | 1056 (57.2) | 453 (49.5) | <0.001 |
| Hypertension (no (%))† | 661 (24.4) | 167 (9.2) | 494 (55.0) | <0.001 |
| Diabetes mellitus (no (%))‡ | 142 (5.5) | 40 (2.3) | 102 (11.8) | <0.001 |
| Creatinine >1.5 mg/dL (no (%))§ | 270 (9.9) | 169 (9.3) | 101 (11.0) | 0.150 |
| Donor type (no (%)) | ||||
| Deceased donor | 2370 (85.8) | 1454 (78.7) | 916 (100.0) | <0.001 |
| Death from cerebrovascular disease¶ | 1323 (55.8) | 627 (43.1) | 696 (76.0) | <0.001 |
| Transplant baseline characteristics | ||||
| Graft rank >1 (no (%)) | 413 (15.0) | 288 (15.6) | 125 (13.7) | 0.177 |
| Cold ischaemia time (no (%))** | ||||
| <12 h | 674 (24.5) | 594 (32.3) | 80 (8.8) | <0.001 |
| 12-24 h | 1560 (56.7) | 910 (49.5) | 650 (71.0) | |
| ≥24 h | 519 (18.8) | 334 (18.2) | 185 (20.2) | |
| Delayed graft function (no (%))††, ‡‡ | 707 (27.2) | 410 (23.5) | 297 (34.7) | <0.001 |
| HLA A/B/DR mismatch (no, mean (SD))§§ | 3.12 (1.43) | 3.07 (1.47) | 3.24 (1.33) | 0.005 |
| Donor specific anti-HLA antibodies on day 0 (no (%)) | 335 (12.1) | 225 (12.2) | 110 (12.0) | 0.896 |
| HLA class of donor specific anti-HLA antibodies (no) | ||||
| HLA class I | 191 | 123 | 68 | 0.214 |
| HLA class II | 245 | 166 | 79 | 0.704 |
| HLA class I and II | 114 | 76 | 38 | 0.889 |
| Donor specific anti-HLA antibodies (mean fluorescence intensity (median (IQR)) | 2928 (1390-6835) | 2755 (1360-6480) | 3005 (1450-8369) | 0.099 |
| Follow-up (years, median (95% CI)) | 5.54 (5.42 to 5.68) | 5.72 (5.54 to 5.86) | 5.24 (5.02 to 5.46) | <0.001 |
| Acute rejection in first year | ||||
| Antibody mediated rejection (no (%)) | 205 (7.4) | 140 (7.6) | 65 (7.1) | 0.648 |
| T cell mediated rejection (no (%)) | 233 (8.4) | 156 (8.5) | 77 (8.4) | 0.972 |
| Death events (no (%)) | 263 (9.5) | 128 (6.9) | 135 (14.7) | <0.001 |
| Graft loss (no (%)) | 333 (12.1) | 187 (10.1) | 146 (15.4) | <0.001 |
Data are no (%) of patients or events, mean (standard deviation), or median (interquartile range). SD=standard deviation; IQR=interquartile range; HLA=human leucocyte antigen.
*χ2 tests used to compare proportions, and unpaired tests used to compare continuous variables.
†Total group numbers were: all patients (n=2709), standard criteria donors (n=1811), and expanded criteria donors (n=898).
‡Total group numbers were: all patients (n=2604), standard criteria donors (n=1741), and expanded criteria donors (n=863).
§Total group numbers were: all patients (n=2736), standard criteria donors (n=1820), and expanded criteria donors (n=916).
¶Total group numbers were: all patients (n=2370), standard criteria donors (n=1454), and expanded criteria donors (n=916).
**Total group numbers were: all patients (n=2753), standard criteria donors (n=1838), and expanded criteria donors (n=915).
††Delayed graft function defined as use of dialysis in the first postoperative week.
‡‡Total group numbers were: all patients (n=2603), standard criteria donors (n=1746), and expanded criteria donors (n=857).
§§Total group numbers were: all patients (n=2700), standard criteria donors (n=1844), and expanded criteria donors (n=856).