Table 2.
Baseline characteristics according to donor status and presence of DSA on the day of transplantation
| SCD/DSA− (n=1622) | SCD/DSA+ (n=225) | ECD/DSA− (n=806) | ECD/DSA+ (n=110) | P* | |
|---|---|---|---|---|---|
| Recipient characteristics | |||||
| Age (years, mean (SD)) | 44.20 (12.20) | 44.76 (11.65) | 59.60 (9.98) | 56.53 (11.41) | <0.001 |
| Male sex (no (%)) | 1001 (61.7) | 104 (46.2) | 489 (60.7) | 49 (44.6) | <0.001 |
| Time since onset of dialysis (years, mean (SD)) | 3.56 (4.28) | 5.93 (6.45) | 3.74 (3.58) | 6.01 (4.91) | <0.001 |
| Donor characteristics | |||||
| Age (years, mean (SD)) | 42.25 (12.50) | 43.01 (12.61) | 66.43 (8.24) | 65.95 (8.67) | <0.001 |
| Donor age (years, no (%)) | |||||
| 0-50 | 1073 (66.1) | 149 (66.2) | 0 | 0 | <0.001 |
| 50-60 | 496 (30.6) | 69 (30.7) | 147 (18.2) | 21 (19.1) | |
| ≥60 | 53 (3.3) | 7 (3.1) | 659 (81.8) | 89 (80.9) | |
| Male sex (no (%)) | 934 (57.6) | 122 (54.2) | 393 (48.8) | 60 (54.6) | 0.001 |
| Hypertension (no (%))† | 142 (8.9) | 25 (11.3) | 427 (54.0) | 67 (62.6) | <0.001 |
| Diabetes mellitus (no (%))‡ | 34 (2.2) | 6 (2.9) | 94 (12.3) | 8 (8.1) | <0.001 |
| Creatinine >1.5 mg/dL (no (%))§ | 155 (9.7) | 14 (6.3) | 94 (11.7) | 7 (6.4) | 0.054 |
| Donor type (no (%)) | |||||
| Deceased donor | 1273 (78.5) | 181 (80.4) | 806 (100) | 110 (100) | <0.001 |
| Death from cerebrovascular disease¶ | 552 (43.4) | 75 (41.4) | 612 (75.9) | 84 (76.4) | <0.001 |
| Transplant baseline characteristics | |||||
| Graft rank >1 (no (%)) | 193 (11.9) | 95 (42.2) | 85 (10.6) | 40 (36.4) | <0.001 |
| Cold ischaemia time (no (%))** | |||||
| <12 h | 544 (33.7) | 50 (22.5) | 70 (8.7) | 10 (9.1) | <0.001 |
| 12-24 h | 803 (49.7) | 107 (48.2) | 575 (71.4) | 75 (68.2) | |
| ≥24 h | 269 (16.6) | 65 (29.3) | 160 (19.9) | 25 (22.7) | |
| Delayed graft function (no (%))†† | 343 (22.4) | 67 (30.9) | 256 (33.9) | 41 (40.2) | <0.001 |
| HLA A/B/DR mismatch (no, mean (SD))‡‡ | 3.07 (1.47) | 3.09 (1.48) | 3.21 (1.32) | 3.44 (1.35) | 0.015 |
| HLA class of donor specific anti-HLA antibodies (no) on day 0 | |||||
| HLA class I | — | 123 | — | 68 | 0.214§§ |
| HLA class II | — | 166 | — | 79 | 0.704§§ |
| HLA class I and II | — | 76 | — | 38 | 0.889§§ |
| Donor specific anti-HLA antibodies (mean fluorescence intensity (median (IQR)) | — | 2755 (1360-6480) | — | 3005 (1450-8369) | <0.001 |
| Follow-up (years, median (95% CI)) | 5.86 (5.70 to 6.12) | 4.66 (4.34 to 4.92) | 5.31 (5.08 to 5.54) | 4.73 (4.24 to 5.19) | <0.001 |
| Acute rejection in the first year | |||||
| Antibody mediated rejection (no (%)) | 78 (4.8) | 62 (27.6) | 31 (3.9) | 34 (30.9) | <0.001 |
| T cell mediated rejection (no (%)) | 142 (8.8) | 14 (6.2) | 66 (8.2) | 11 (10.0) | 0.561 |
| Death events (no (%)) | 108 (6.7) | 20 (8.9) | 118 (14.6) | 17 (15.5) | <0.001 |
| Graft loss (no (%)) | 146 (9.0) | 41 (18.2) | 103 (12.8) | 43 (39.1) | <0.001 |
Data are no (%) of patients or events, mean (standard deviation), or median (interquartile range). SD=standard deviation; IQR=interquartile range; HLA=human leucocyte antigen; SCD=standard criteria donors; ECD=expanded criteria donors; DSA=donor specific anti-HLA antigen.
*χ2 tests or Fisher’s exact tests used to compare proportions, and ANOVA or Kruskal-Wallis test used to compare continuous variables between the four groups.
†Total group numbers were: SCD/DSA− (n=1589), SCD/DSA+ (n=222), ECD/DSA− (n=791), and ECD/DSA+ (n=107).
‡Total group numbers were: SCD/DSA− (n=1533), SCD/DSA+ (n=208), ECD/DSA− (n=764), and ECD/DSA+ (n=99).
§Total group numbers were: SCD/DSA− (n=1598), SCD/DSA+ (n=222), ECD/DSA− (n=806), and ECD/DSA+ (n=110).
¶Total group numbers were: SCD/DSA− (n=1273), SCD/DSA+ (n=181), ECD/DSA− (n=806), and ECD/DSA+ (n=110).
**Total group numbers were: SCD/DSA− (n=1616), SCD/DSA+ (n=222), ECD/DSA− (n=805), and ECD/DSA+ (n=110).
†† Delayed graft function defined as use of dialysis in the first postoperative week. Total group numbers were: SCD/DSA− (n=1529), SCD/DSA+ (n=217), ECD/DSA− (n=755), and ECD/DSA+ (n=102).
‡‡Total group numbers were: SCD/DSA− (n=1619), SCD/DSA+ (n=225), ECD/DSA− (n=752), and ECD/DSA+ (n=104).
§§P values represent the comparison between the SCD/DSA+ and ECD/DSA+ groups.