Table 3 .
Factors associated with kidney allograft loss in univariate analyses
| No of patients/events | Hazard ratio (95% CI) | P | |
|---|---|---|---|
| Baseline recipient characteristics | |||
| Age (per 1 year increment) | 2763/333 | 1.000 (0.992 to 1.008) | 0.973 |
| Sex | |||
| Female | 1120/131 | 1 | 0.648 |
| Male | 1643/202 | 1.053 (0.845 to 1.311) | |
| Baseline donor characteristics | |||
| Age (per 1 year increment) | 2763/333 | 1.014 (1.007 to 1.021) | <0.001 |
| Sex | |||
| Female | 1254/163 | 1 | 0.164 |
| Male | 1509/170 | 0.858 (0.692 to 1.064) | |
| Donor type | |||
| Living related | 393/25 | 1 | 0.001 |
| Death from cardiovascular disease | 1323/184 | 2.136 (1.406 to 3.245) | |
| Other cause of death | 1047/124 | 1.716 (1.116 to 2.638) | |
| Deceased donor | |||
| No | 393/25 | 1 | 0.001 |
| Yes | 2370/308 | 1.945 (1.294 to 2.925) | |
| Hypertension | |||
| No | 2048/225 | 1 | <0.001 |
| Yes | 661/102 | 1.647 (1.302 to 2.082) | |
| Diabetes mellitus | |||
| No | 2462/292 | 1 | 0.050 |
| Yes | 142/22 | 1.543 (1.000 to 2.380) | |
| Creatinine | |||
| <1.5 mg/dL | 2466/291 | 1 | 0.900 |
| ≥1.5 mg/dL | 270/40 | 0.964 (0.547 to 1.700) | |
| Expanded criteria donor | |||
| No | 1847/187 | 1 | <0.001 |
| Yes | 916/146 | 1.869 (1.504 to 2.323) | |
| Baseline transplant characteristics | |||
| Graft rank | <0.001 | ||
| 1 | 2350/249 | 1 | |
| >1 | 413/84 | 2.174 (1.697 to 2.785) | |
| Cold ischaemia time | |||
| <12 h | 674/44 | 1 | <0.001 |
| 12-24 h | 1560/203 | 1.877 (1.355 to 2.601) | |
| ≥24 h | 519/85 | 2.392 (1.662 to 3.443) | |
| Baseline immunological characteristics | |||
| No of HLA A/B/DR mismatches | 2700/326 | 1.080 (1.001 to 1.116) | 0.047 |
| Anti-HLA DSA on day 0 | |||
| No | 2428/249 | 1 | <0.001 |
| Yes | 335/84 | 3.440 (2.676 to 4.421) | |
DSA=donor specific anti-HLA antibodies; HLA=human leucocyte antigen.