Table 4.
Factors associated with kidney allograft loss in the multivariate analysis*
| No of patient/events | Hazard ratio (95% CI) | P | Internal validation hazard ratio 95% CI, BCA | |
|---|---|---|---|---|
| Expanded criteria donor | ||||
| No | 1835/187 | 1 | <0.001 | — |
| Yes | 855/138 | 1.842 (1.467 to 2.311) | (1.463 to 2.275) | |
| Cold ischaemia time | ||||
| <12 h | 670/44 | 1 | 0.017 | — |
| 12-24 h | 1514/198 | 1.457 (1.042 to 2.039) | (1.042 to 2.093) | |
| ≥24 h | 506/83 | 1.727 (1.185 to 2.517) | (1.195 to 2.506) | |
| Graft rank | ||||
| 1 | 2278/241 | 1 | 0.002 | — |
| >1 | 412/84 | 1.544 (1.168 to 2.042) | (1.129 to 2.046) | |
| No of HLA A/B/DR mismatches | 2690/325 | 1.095 (1.013 to 1.184) | 0.022 | (1.013 to 1.182) |
| Anti-HLA DSA on day 0 | ||||
| No | 2364/241 | 1 | <0.001 | — |
| Yes | 326/84 | 2.988 (2.265 to 3.941) | (2.198 to 3.940) | |
DSA=donor specific anti-HLA antibodies; BCA=bias corrected and accelerated bootstrap; HLA=human leucocyte antigen.
*The final multivariate Cox model was obtained by entering risk factors from the univariate model that achieved P≤0.10 as the thresholds in a single multivariate proportional hazards model. The final multivariate model was adjusted for the following parameters: deceased donor, donor diabetes, expanded criteria donor, graft rank, cold ischaemia time, number of HLA A/B/DR mismatches, and circulating DSA. The test for potential interactions between graft rank, ECD status, cold ischaemia time, HLA mismatch, and circulating DSA generated P>0.10 for all the interactions.