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. Author manuscript; available in PMC: 2016 Jul 27.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Jun 12;54(31):9047–9051. doi: 10.1002/anie.201503297

Table 5.

Alkyl–alkyl cross-couplings to generate trifluoromethyl-substituted products: scope with respect to the electrophile.[a]

graphic file with name nihms711211u6.jpg
entry alkyl yield (%)[b]
1 graphic file with name nihms711211t27.jpg 86
2 graphic file with name nihms711211t28.jpg 79
3 graphic file with name nihms711211t29.jpg 76
4[c] graphic file with name nihms711211t30.jpg 72
5 graphic file with name nihms711211t31.jpg 83
6[c] graphic file with name nihms711211t32.jpg 81
7 graphic file with name nihms711211t33.jpg 80
8 graphic file with name nihms711211t34.jpg 86
[a]

All data are the average of two experiments.

[b]

Yield of purified product.

[c]

Nucleophile: BrZnCH2CH2CH2CN.